Symbiosis Centre for Stem Cell Research (SCSCR)

Symbiosis Centre for Stem Cell Research (SCSCR) was established as a new initiative of Symbiosis International (Deemed University) on 29th July 2016. SCSCR is located at the hill base campus within Symbiosis School of Biological Sciences (SSBS), under the Faculty of Medical and Health Sciences (FoHMS). The centre is a unique research centre in Pune that will perform research exclusively on stem cells.

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Head’s message

Welcome to Symbiosis Centre for Stem Cell Research (SCSCR) at Symbiosis International (Deemed University). SCSCR is strategically located in Symbiosis School of Biological Sciences (SSBS), providing an ideal ecosystem for the interaction of SCSCR faculty with the faculty members of SSBS. Most importantly, the location of SCSCR at the hill base campus, opposite the multi-specialty Symbiosis University Hospital & Research Centre (SUHRC), helps in bridging the gap between laboratory research and clinical practices.

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News

Ms. Nidhi Sapre, a PhD student under the supervision of Dr. Ruchi Mishra Tiwari at Symbiosis Centre for Stem Cell Research (SCSCR), has been awarded the Sohan P.

Congratulations to Dr. Isha Behere for successfully completing her PhD defense on 13th October 2025.

Workshop I on "Stem Cell Biology: From Basics to Applications" was successfully conducted on 18th September2025 at SCSCR.

Team members

SCSCR members

Infrastructure

Projects

  1. Molecular Analyses of extra-cellular vesicles isolated from bone marrow derived mesenchymal stromal cells treated with specific signalling modifiers and assessment of their effects on the fate of hematopoietic stem cells- Funded by Department of Biotechnology (2018-2021, 47.6 lakhs). PI – Dr. Anuradha Vaidya, Co-PI: Dr. Lalita Limaye, Dr. Srikanth Rapole and Dr. Vaijayanti Kale

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Research

  • 1. Experimental Hematology
  • I) Microenvironment-mediated regulation of Hematopoietic Stem Cells:
  • (A) Priming of MSCs to boost their hematopoiesis-supportive ability

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Collaborators

Funding

Publications

2025

105. Pendse S, Chavan S, Kasherwal V, Kale V, Vaidya A. Pharmacological Inhibition of NF-κB in Mesenchymal Stromal Cells Selectively Partitions Apoptosis-Inducing Factors in Their Microvesicles and Proliferation-Inducing Factors in Their Exosomes: Implications in the Management of Acute Myeloid Leukemia. Cell Biol Int. 2026 Jan;50(1):e70113. doi: 10.1002/cbin.70113. PMID: 41405680.

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2024

104. Suthar JK, Vaidya A, Ravindran S. Impact of particle size and surface modifications on the neurotoxic potential of copper oxide nanoparticles. Sci Rep. 2025 Dec 24;15(1):44532. doi: 10.1038/s41598-025-28114-2. PMID: 41444298; PMCID: PMC12738751.

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2023

103. Pendse S, Kale V, Vaidya A. Microvesicles secreted by CoCl2-primed mesenchymal stromal cells boost the functionality of hematopoietic stem cells cultured with them. Ann Hematol. 2025 Oct;104(10):5389-5402. doi: 10.1007/s00277-025-06652-z. Epub 2025 Oct 7. PMID: 41055736; PMCID: PMC12619781.

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2022

102. Nandan A, Mangeshikar A, Kale V, Vaidya A, Pethe P. Correlation between Polycomb repressive complex proteins and epithelial-mesenchymal transition-associated genes in endometriotic tissues. Reprod Biol. 2025 Dec 19;26(1):101173. doi: 10.1016/j.repbio.2025.101173.

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2021

101. Dumasia NP, Pethe PS. RING1B-BMI1 catalyzed dynamic H2AK119ub1 modification in response to sonic hedgehog signalling during pancreatic differentiation of human embryonic stem cells. Sci Rep. 2025 Nov 28;15(1):42814. doi: 10.1038/s41598-025-27698-z. PMID: 41315527; PMCID: PMC12663276.

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2020

100. Dixit T, Aswini A, Nikam H, Vaidya A, Ravindran S. Emerging trends in synthesis, characterization, and mechanism of action of antibody-drug and antibody-nanoparticle conjugates. Discov Nano. 2025 Aug 18;20(1):139. doi: 10.1186/s11671-025-04303-w. PMID: 40824329; PMCID: PMC12361037.

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2019

99. Holkar K, Pethe P, Kale V , Ingavle G. Engineering a cell-free bone regeneration platform using osteogenically primed MSC-EVs and nHAp-enriched IPN hydrogels. Regen Med. 2025 Sep 8:1-12. doi: 10.1080/17460751.2025.2557770.

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2018

98. Holkar K, Pethe P, Kale V, Ingavle G. Microsphere-Mediated Sustained Delivery of Growth Factors Stimulates Osteogenesis in Target Cells in a Three-Dimensional Microenvironment. J Biomed Mater Res A. 2025 Jun;113(6):e37947. doi: 10.1002/jbm.a.37947. PMID: 40499148.

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Multimedia

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