Symbiosis Centre for Stem Cell Research (SCSCR)

Symbiosis Centre for Stem Cell Research (SCSCR) was established as a new initiative of Symbiosis International (Deemed University) on 29th July 2016. SCSCR is located at the hill base campus within Symbiosis School of Biological Sciences (SSBS), under the Faculty of Health Sciences (FoHS). The centre is a unique research centre in Pune that will perform research exclusively on stem cells.

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Head’s message

Welcome to Symbiosis Centre for Stem Cell Research (SCSCR) at Symbiosis International (Deemed University). SCSCR is strategically located in Symbiosis School of Biological Sciences (SSBS), providing an ideal ecosystem for the interaction of SCSCR faculty with the faculty members of SSBS. Most importantly, the location of SCSCR at the hill base campus, opposite the multi-specialty Symbiosis University Hospital & Research Centre (SUHRC), helps in bridging the gap between laboratory research and clinical practices.

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The Department of Biotechnology (DBT) has recommended the project proposal entitled “Investigating the osteogenic potential of extracellular vesicles loaded injectable hydrogels” for funding of Rs. 36.50 lakhs for three years. This project will develop injectable hydrogels to investigate the osteogenic potential of stem cell-derived extracellular vesicles (EVs) for bone tissue repair (PI: Dr. Ganesh Ingavle, Co-PI’s: Dr. Vaijayanti Kale and Dr. Prasad Pethe).

The Department of Biotechnology (DBT) has also recommended another proposal entitled “Investigating the role of histone deubiquitinases in human pluripotent stem cell differentiation” for funding of Rs. 34.17 lakhs. Results of this study will help us understand the role of histone deubiquitinases during lineage specification in human ES cells (PI: Dr. Prasad Pethe and Co-PI: Dr. Vaijayanti Kale).

Neuronal regeneration using extra cellular vesicles isolated from murine bone marrow derived mesenchymal stromal cells: An in vitro study using cell model. Funded by Symbiosis International University (2020-2022, 10 lakhs). PI – Dr. Anuradha Vaidya.

Team members

SCSCR members



  1. Molecular Analyses of extra-cellular vesicles isolated from bone marrow derived mesenchymal stromal cells treated with specific signalling modifiers and assessment of their effects on the fate of hematopoietic stem cells- Funded by Department of Biotechnology (2018-2021, 47.6 lakhs). PI – Dr. Anuradha Vaidya, Co-PI: Dr. Lalita Limaye, Dr. Srikanth Rapole and Dr. Vaijayanti Kale

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  • 1. Experimental Hematology
  • I) Microenvironment-mediated regulation of Hematopoietic Stem Cells:
  • (A) Priming of MSCs to boost their hematopoiesis-supportive ability

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75. Pendse S, Chavan S,Kale V, Vaidya A. A comprehensive analysis of cell-autonomous and non-cell-autonomous regulation of myeloid leukemic cells: The prospect of developing novel niche-targeting therapies. Cell Biol Int. 2023 Aug 9. doi: 10.1002/cbin.12078. Epub ahead of print. PMID: 37554060.

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66. Pallavi Budgude, Prajakta Teli, Anuradha Vaidya and Vaijayanti Kale (2022) The Role of Autophagy in the Regulation of Hematopoietic Stem Cells. In Autophagy in Stem Cell Maintenance and Differentiation. Series: Stem Cell Biology and Regenerative Medicine. Editors: Bhupendra V. Shravage · Kursad Turksen. ISBN: 978-3-031-17361-5, ISBN 978-3-031-17362-2 (eBook) Book Chapter.

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51. Das M, Kale V. Involvement of Extracellular vesicles in aging process and their beneficial effects in alleviating aging-associated symptoms. Accepted in Cell Biology International, 2021.

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33. Das, M., Kale, V. Extracellular vesicles: Mediators of embryo-maternal crosstalk during pregnancy and a new weapon to fight against infertility. (2020) Eur J Cell Biol 99 (8), art. no. 151125, .

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19. Kale, V.P. Application of "primed" Mesenchymal Stromal Cells in Hematopoietic Stem Cell Transplantation: Current Status and Future Prospects. (2019) Stem Cell Dev 28 (22), pp. 1473-1479.

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4. Vaidya, A., Kale, V., Poonawala, M., Ghode, S. Mesenchymal stromal cells enhance the hematopoietic stem cell-supportive activity of resveratrol. (2018) Regen Med 13 (4), pp. 409-425.

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